Methoxetamine

Buy Methoxetamine MXE Powder Online

Buy Methoxetamine MXE Powder Online, Methoxetamine, abbreviated as MXE, is a dissociative
hallucinogen that has been sold as a designer drug.It differs from many dissociatives such as
ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as
general anesthetics in that it was designed for grey market distribution.

MXE is an aryicyclohexylamine.it acts mainly as an NMDA receptor antagonist, similarly to other
aryicyclohexylamines like ketamine and PCP.Buy Methoxetamine MXE Powder For Online

MXE is reported to have a similar effect to ketamine.|t was often believed to possess opioid
properties due to its structural similarity to 3~HO-PCPbut this assumption is not supported by
data, which shows insignificant affinity for the :-opioid receptor by the compound.Recreational
use of MXE has been associated with hospitalizations from high and/or combined consumption in
the US and UK.Acute reversible cerebellar toxicity has been documented in three cases of hospital
admission due to MXE overdose, lasting for between one and four days after exposure.

MXE was designed in part in an attempt to avoid the urotoxicity associated with ketamine abuse; it
was thought the compound’s increased potency and reduced dose would limit the accumulation of
urotoxic metabolites in the bladder.Like ketamine, MXE has been found to produce bladder
inflammation and fibrosis after high dose, chronic administration in mice (although the dosages
used were quite large).Reports of urotoxicity in humans have yet to appear in the medical
literature.

MXE acts mainly as a selective and high-affinity NMDA receptor antagonist, specifically of the
dizocilpine (MK-801) site (Ki = 257 nM).|t produces ketamine-like effects.

In addition to antagonism of the NMDA receptor, MXE has been found to act as a serotonin
reuptake inhibitor (Ki = 479 nM; IC50 = 2,400 nM).Conversely, it shows little or no effect on the
reuptake of dopamine and norepinephrine (Ki and IC50 > 10,000 nM).Nonetheless, MXE has been
found to activate dopaminergic neurotransmission, including in the mesolimbic reward
pathway.This is a characteristic that it shares with other NMDA receptor antagonists, including
ketamine, PCP, and dizocilpine (MK-801).Animal studies suggest MXE may have rapidly-acting
antidepressant effects similar to those of ketamine.A study that assessed binding of MXE at 56
sites including Buy Methoxetamine MXE Powder Online neurotransmitter receptors and
transporters found that MXE had Ki values of >10,000 nM for all sites except the dizocilpine site of
the NMDA receptor and the serotonin transporter (SERT).